Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …
Symptomatic and disease-modifying therapy pipeline for Alzheimer's disease: Towards a personalized polypharmacology patient-centered approach
Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …
Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors
AA Sproul, S Jacob, D Pre, SH Kim, MW Nestor… - PloS one, 2014 - journals.plos.org
Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations
are the most common cause of early onset familial Alzheimer's disease (FAD). In order to …
are the most common cause of early onset familial Alzheimer's disease (FAD). In order to …
Loss of caveolin-1 accelerates neurodegeneration and aging
Background The aged brain exhibits a loss in gray matter and a decrease in spines and
synaptic densities that may represent a sequela for neurodegenerative diseases such as …
synaptic densities that may represent a sequela for neurodegenerative diseases such as …
Animal models of Alzheimer's disease: preclinical insights and challenges
QQ Xu, W Yang, M Zhong, ZX Lin, NE Gray… - Acta Materia …, 2023 - scienceopen.com
Alzheimer's disease (AD), an irreversible neurodegenerative disease that progressively
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …
The retina as a window or mirror of the brain changes detected in Alzheimer's disease: critical aspects to unravel
S Chiquita, AC Rodrigues-Neves, FI Baptista… - Molecular …, 2019 - Springer
Alzheimer's disease is the most frequent cause of dementia worldwide, representing a
global health challenge, with a massive impact on the quality of life of Alzheimer's disease …
global health challenge, with a massive impact on the quality of life of Alzheimer's disease …
Modeling human neurodegenerative diseases in transgenic systems
MA Gama Sosa, R De Gasperi, GA Elder - Human genetics, 2012 - Springer
Transgenic systems are widely used to study the cellular and molecular basis of human
neurodegenerative diseases. A wide variety of model organisms have been utilized …
neurodegenerative diseases. A wide variety of model organisms have been utilized …
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease
LK Hamilton, A Aumont, C Julien… - European Journal of …, 2010 - Wiley Online Library
Alzheimer's disease (AD) affects cognitive modalities that are known to be regulated by adult
neurogenesis, such as hippocampal‐and olfactory‐dependent learning and memory …
neurogenesis, such as hippocampal‐and olfactory‐dependent learning and memory …
Alzheimer's disease and epilepsy: a perspective on the opportunities for overlapping therapeutic innovation
L Lehmann, A Lo, KM Knox, M Barker-Haliski - Neurochemical research, 2021 - Springer
Early-onset Alzheimer's disease (AD) is associated with variants in amyloid precursor
protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly recognized that patients with …
protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly recognized that patients with …