Prostate-Specific Membrane Antigen–Targeted Therapies for Prostate Cancer: Towards Improving Therapeutic Outcomes

M Corpetti, C Müller, H Beltran, J de Bono… - European Urology, 2023 - Elsevier
Context Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein
overexpressed in most prostate cancers and exploited as a target for PSMA-targeted …

Joint EANM/SNMMI procedure guideline for the use of 177Lu-labeled PSMA-targeted radioligand-therapy (177Lu-PSMA-RLT)

C Kratochwil, WP Fendler, M Eiber, MS Hofman… - European journal of …, 2023 - Springer
Prostate-specific membrane antigen (PSMA) is expressed by the majority of clinically
significant prostate adenocarcinomas, and patients with target-positive disease can easily …

177Lu‐PSMA radioligand therapy effectiveness in metastatic castration‐resistant prostate cancer: An updated systematic review and meta‐analysis

MS Sadaghiani, S Sheikhbahaei, RA Werner… - The …, 2022 - Wiley Online Library
Background An updated systematic review and meta‐analysis of relevant studies to
evaluate the effectiveness of prostate‐specific membrane antigen (PSMA)‐targeted …

Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer

MK Bakht, Y Yamada, SY Ku, VB Venkadakrishnan… - Nature cancer, 2023 - nature.com
Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15–20% of men
with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain …

177 Lu-PSMA-617 radioligand therapy of metastatic castration-resistant prostate cancer: Initial 254-patient results from a prospective registry (REALITY Study)

F Khreish, Z Ghazal, RJ Marlowe, F Rosar… - European Journal of …, 2022 - Springer
Purpose Preliminary data from retrospective analyses and recent data from large
randomized controlled trials suggest safety and efficacy of radioligand therapy (RLT) …

Extended therapy with [177Lu]Lu-PSMA-617 in responding patients with high-volume metastatic castration-resistant prostate cancer

N Mader, C Nguyen Ngoc, B Kirkgöze… - European Journal of …, 2023 - Springer
Purpose The currently used scheme for radioligand therapy (RLT) of patients with metastatic
castration-resistant prostate cancer (mCRPC) consists of 4–6 cycles of 6.0–7.4 GBq [177Lu] …

Efficacy and Safety of [225Ac]Ac-PSMA-617 Augmented [177Lu]Lu-PSMA-617 Radioligand Therapy in Patients with Highly Advanced mCRPC with Poor Prognosis

F Rosar, J Krause, M Bartholomä, S Maus, T Stemler… - Pharmaceutics, 2021 - mdpi.com
The use of 225Ac in prostate-specific membrane antigen (PSMA)-targeted radioligand
therapy (RLT), either as monotherapy or in combination with 177Lu, is a promising therapy …

Neo-construction of a SO2-tunable near-infrared ratiometric fluorescent probe for high-fidelity diagnosis and evaluation hazards of Cd2+-induced liver injury

X Yuan, T Liu, K Luo, C Xie, L Zhou - Journal of Hazardous Materials, 2024 - Elsevier
Cadmium-contaminated water and food are seriously hazardous to the human health,
especially liver injury. To understand the entanglement relationship between cadmium ion …

Optimizing PSMA radioligand therapy for patients with metastatic castration-resistant prostate cancer. A systematic review and meta-analysis

FE von Eyben, G Bauman, R von Eyben… - International Journal of …, 2020 - mdpi.com
The aim of the review was to evaluate patient and treatment characteristics for patients with
metastatic castration-resistant prostate cancer (mCRPC) treated with PSMA radioligand …

Visceral metastases as predictors of response and survival outcomes in patients of castration-resistant prostate cancer treated with 177Lu-labeled prostate-specific …

S Satapathy, BR Mittal, A Sood - Clinical Nuclear Medicine, 2020 - journals.lww.com
Background The presence of visceral metastases is associated with poor prognosis in
patients of metastatic castration-resistant prostate cancer (mCRPC) treated with hormonal …