Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

This review addresses pharmacological, structural and functional relationships among H2-
histamine receptors and H1-histamine receptors in the mammalian heart. The role of both …

Pannexin 1 channels located in the cell membrane are permeable to ions, metabolites, and
signaling molecules. While the activity of these channels is known to be modulated by …

The histamine H4 receptor (H4R) activates Gαi-mediated signaling and recruits β-arrestin2
upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled …

Acute myeloid leukemia (AML) consists in a cancer of early hematopoietic cells arising in the
bone marrow, most often of those cells that would turn into white blood cells (except …

Abstract Histamine H2 receptor (H2R) is a member of G protein‐coupled receptor family.
Agonist stimulation of H2R results in several cellular events including activation of adenylate …

G 蛋白偶联受体激酶(G protein-coupled receptor kinases, GRKs) 不仅调节G
蛋白偶联受体(GPCR) 磷酸化, 介导受体脱敏, 使信号效应降低或消失, 而且也调节G …

Abstract Histamine H 3 receptors (H 3 Rs) signal through Gα i/o proteins and are found in
neuronal cells as auto-and hetero-receptors. Alternative splicing of the human H 3 R (hH 3 …

As the largest known family of cell surface receptors and the most common therapeutic drug
targets, G protein-coupled receptors (GPCRs) are at the center of modern medicine. Multiple …

G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral
membrane proteins to which histamine receptors belong. Increasing numbers of proteins …