Antioxidants in brain tumors: current therapeutic significance and future prospects

X Qi, SK Jha, NK Jha, S Dewanjee, A Dey, R Deka… - Molecular Cancer, 2022 - Springer
Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor
microenvironment and inherent characteristics of brain tumor cells virtually render them …

The role of natural products as inhibitors of JAK/STAT signaling pathways in glioblastoma treatment

H Fahmideh, H Shapourian, R Moltafeti… - Oxidative medicine …, 2022 - Wiley Online Library
The permeability of glioblastoma, as well as its escaping the immune system, makes them
one of the most deadly human malignancies. By avoiding programmed cell death …

[HTML][HTML] Low-intensity pulsed ultrasound-mediated blood-brain barrier opening increases anti-programmed death-ligand 1 delivery and efficacy in Gl261 mouse …

MH Ahmed, I Hernández-Verdin, E Quissac, N Lemaire… - Pharmaceutics, 2023 - mdpi.com
Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical
trials in glioblastoma (GBM) patients. Ultrasound-mediated blood–brain barrier opening …

Current perspective on the natural compounds and drug delivery techniques in glioblastoma multiforme

T Behl, A Sharma, L Sharma, A Sehgal, S Singh… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma multiforme (GBM) is one of the belligerent neoplasia that
metastasize to other brain regions and invade nearby healthy tissues. However, the …

Exopolysaccharides of fungal origin: properties and pharmaceutical applications

RM Stoica, M Moscovici, ES Lakatos, LI Cioca - Processes, 2023 - mdpi.com
Fungal exopolysaccharides (EPSs) represent an important group of bioactive compounds
secreted by fungi. These biopolymers can be utilized individually or in combination with …

Neuroimmunomodulatory properties of flavonoids and derivates: a potential action as adjuvants for the treatment of glioblastoma

RP do Nascimento, BL Dos Santos, JAO Amparo… - Pharmaceutics, 2022 - mdpi.com
Glioblastomas (GBMs) are tumors that have a high ability to migrate, invade and proliferate
in the healthy tissue, what greatly impairs their treatment. These characteristics are …

Design and computational analysis of an MMP9 inhibitor in hypoxia-induced glioblastoma multiforme

S Kumari, P Kumar - ACS omega, 2023 - ACS Publications
The main therapeutic difficulties in treating hypoxia-induced glioblastoma multiforme (GBM)
are toxicity of current treatments and the resistance brought on by the microenvironment …

Challenges and perspectives of standard therapy and drug development in high-grade gliomas

SS Chelliah, EAL Paul, MNA Kamarudin, I Parhar - Molecules, 2021 - mdpi.com
Despite their low incidence rate globally, high-grade gliomas (HGG) remain a fatal primary
brain tumor. The recommended therapy often is incapable of resecting the tumor entirely …

[HTML][HTML] Matteucinol combined with temozolomide inhibits glioblastoma proliferation, invasion, and progression: an in vitro, in silico, and in vivo study

JB Netto, ESA Melo, AGS Oliveira, LR Sousa… - Brazilian Journal of …, 2022 - SciELO Brasil
Glioblastoma is the most prevalent and malignant brain tumor identified in adults. Surgical
resection followed by radiotherapy and chemotherapy, mainly with temozolomide (TMZ), is …

Target-based virtual screening and molecular interaction studies for lead identification of natural olive compounds against glioblastoma multiforme

A Ghosh, D Chakraborty, N Mukerjee… - … Science and Pollution …, 2023 - Springer
Glioblastoma multiforme, a rare traumatic brain disorder, is at the research climax for its
uncontrolled growth leading to a catastrophic outcome. Throwing light on the target-based …