Transposon-based gene vectors have become indispensable tools in vertebrate genetics for
applications ranging from insertional mutagenesis and transgenesis in model species to …

Genetic modification of clinical-grade T cells is undertaken to augment function, including
redirecting specificity for desired antigen. We and others have introduced a chimeric antigen …

The stable introduction of therapeutic transgenes into human cells can be accomplished
using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses …

Retroviral insertion mutagenesis screens in mice are powerful tools for efficient identification
of oncogenic mutations in an in vivo setting. Many oncogenes identified in these screens …

Transposable elements can be considered as natural, nonviral gene-delivery vehicles and
are valuable and widely used tools for germ-line transgenesis and insertional mutagenesis …

Abstract The Sleeping Beauty (SB) transposable element is a promising vector for
transgenesis in vertebrates and is being developed as a novel, nonviral system for gene …

Gene therapy protocols require robust and long-term gene expression. For two decades,
retrovirus family vectors have offered several attractive properties as stable gene-delivery …

Gene transfer to T lymphocytes has historically relied on retro and lentivirus, but recently
transposon-based gene transfer is rising as a simpler and straight forward approach to …

Chimeric antigen receptor T‐cells (CAR T‐cells) represent a novel and promising approach
in cancer immunotherapy. According to the World Health Organization (WHO), the number of …

The advent of efficient approaches to the genetic modification of T cells has provided
investigators with clinically appealing methods to improve the potency of tumor‐specific …