It has been previously shown that integrase-defective HIV-1-based gene vectors can serve,
with moderate efficiency, as substrate for DNA transposition by a transiently expressed …

Background DNA transposons have emerged as indispensible tools for manipulating
vertebrate genomes with applications ranging from insertional mutagenesis and …

Motivation Genetic diversity of non-model organisms offers a repertoire of unique phenotypic
features for exploration and cultivation for synthetic biology and metabolic engineering …

Infusion of patient-derived CD19-specific chimeric antigen receptor (CAR) T cells
engineered by viral vectors achieved complete remission and durable response in relapsed …

Transposable elements make up a significant fraction of many eukaryotic genomes.
Although both classes of transposable elements, the DNA transposons and the …

Lentiviral vectors enter cells with high efficiency and deliver stable transduction through
integration into host chromosomes, but their preference for integration within actively …

A major problem in gene therapy is the determination of the rates at which gene transfer has
occurred. Our work has focused on applications of the Sleeping Beauty (SB) transposon …

International Review of Cell and Molecular Biology presents current advances and
comprehensive reviews in cell biology--both plant and animal. Articles address structure and …

ABCA3 is a phospholipid transporter implicated in pulmonary surfactant homoeostasis and
localized at the limiting membrane of lamellar bodies, the storage compartment for surfactant …

Mutations in the ATP‐binding cassette subfamily A member 3 (ABCA3) gene are the most
common monogenetic cause of surfactant dysfunction disorders in newborns and interstitial …