Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Importance Obstructive sleep apnea (OSA) is the most common clinically significant
breathing abnormality during sleep. It is highly prevalent among patients with atrial …

Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …