The ideal drug discovery process of new platinum based drugs should take into account
three basic fundaments: on one side the mechanisms of action and the corresponding target …

In attempts to overcome the drawbacks of cisplatin-severe toxicity, drug resistance and poor
oral bioavailability-the development of platinum-based drugs has progressed from …

Summary Chemical-, pharmacological-, and clinical-research on anticancer coordination
complexes has yielded remarkable anticancer agents such as cisplatin, carboplatin, and …

Platinum (Pt)-containing drugs are currently used in the clinic for treating various types of
cancers, including testicular germ-cell tumors, small cell lung cancer, colon carcinoma …

Sixteen platinum (II) complexes of estrone and estradiol were synthesized in this work to
evaluate their cytotoxic activity against several cancer cell lines including estrogen …

Complexes [Pt (2Bz4oT) Cl],[Pt (2Bz4mT) Cl], and [Pt (2Bz4pT) Cl] were prepared with N (4)-
ortho-(H2Bz4oT), N (4)-meta-(H2Bz4mT), and N (4)-para-(H2Bz4pT) tolyl-2-benzoylpyridine …

The conformational behavior of the third generation antitumor drug, oxaliplatin, has been
explored by GGA-PW91 density functional calculations and FT-IR spectra. The difference in …

Ten new organoplatinum (II) complexes,[PtCl (Saf)(8-OQ)](1),[Pt (Saf-1H)(8-OQ)](2),[PtCl
(Meug)(8-OQ)](3),[Pt (Meug-1H)(8-OQ)](4),[PtCl (Meteug)(8-OQ)](5),[PtCl (Meteug)(Q)](6),[Pt …

The two new mononuclear complexes were prepared by reacting symmetric Schiff base,
containing pyrimidine rings and the metal chlorides of Pd (II) and Pt (II) in methanol. The …

Three distinctive end group-containing organotin (IV) carboxylates complexes (YDCOOSn,
CLCOOSn and BZCOOSn) were designed and synthesized. Together with theoretical …