Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Pulmonary arterial hypertension (PAH) is a debilitating multifactorial disease characterized
by progressive pulmonary vascular remodeling, elevated pulmonary arterial pressure, and …

Exosomes are emerging in tissue engineering as up-and-coming acellular therapeutics,
circumventing common restrictions inherent to cell-based therapies. The characteristics and …

Cellular therapy to treat heart failure is an ongoing focus of intense research, but progress
toward structural and functional recovery remains modest. Engineered augmentation of …

Pediatric patients with congenital heart defects (CHD) often present with heart failure from
increased load on the right ventricle (RV) due to both surgical methods to treat CHD and the …

Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle (RV)
caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction leading …

Cardiac mesenchymal stem cells (C-MSCs) are a novel mesenchymal stem cell (MSC)
subpopulation derived from cardiac tissue, which are reported to be responsible for cardiac …

Congenital heart disease is the number one cause of birth defect-related death because it
often leads to right ventricular heart failure (RVHF). One promising avenue to combat this …

The human brain formation involves complicated processing, which is regulated by a gene
regulatory network influenced by different signaling pathways. The cross-regulatory …

BACKGROUND: Stem cells are used as an alternative treatment option for patients with
congenital heart disease (CHD) due to their regenerative potential, but they are subject to …