Comprehensive Approach to Cancer Immunotherapy–Simultaneous Targeting of Myeloid-derived Suppressor Cells and Cancer Cells with AFP Conjugates

VN Pak, IA Sherman - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
The immune system plays a pivotal role in combating diseases, including cancer, with
monocytes emerging as key regulators of immune response dynamics. This article describes …

Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review

V Silva, C Matos - Clinical and Translational Oncology, 2024 - Springer
Introduction Treatment of cancer has been improved with the discovery of biological drugs
that act as immune checkpoint inhibitors. In 2017, FDA designated pembrolizumab, an …

[HTML][HTML] The possible drug for cancer and metastasis prevention

VN Pak - Future Drug Discovery, 2022 - Taylor & Francis
One in two people will be diagnosed with cancer in their lifetime in developed countries.
Prophylactics and early diagnostics are recommended to everyone. On the other hand, even …

Alpha-Fetoprotein: A Revolutionary Anti-Cancer Drug

VN Pak - Medical Research Archives, 2023 - esmed.org
Alpha-fetoprotein is an oncofetal protein the embryo produces during fetal development. The
protein serves two critical functions simultaneously: it delivers nutrients to growing embryo …

Alpha-Fetoprotein Binds Toxins and Can Be Used to Treat Cancer

VN Pak - Medical Research Archives, 2022 - esmed.org
The inefficiency of the immune system to kill cancer cells leads to the disease. Like in
pregnancy, oncofetal proteins counteract the immune attack. Alpha-fetoprotein is an …

[HTML][HTML] Alpha-fetoprotein as a Shuttle for Medicines

VN Pak - pharmafocusasia.com
Alpha-fetoprotein (AFP) delivers ligands to monocytes/macrophages that regulate the
immune system activity. AFP or AFP-drugs can be used to treat autoimmune diseases, while …