The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds
derived principally from fatty acids, that can be metabolised by many oxidative tissues …

Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To
determine whether accumulation of very long–chain ceramides occurs in human failing …

In the advanced stages of heart failure, many key enzymes involved in myocardial energy
substrate metabolism display various degrees of down-regulation. The net effect of the …

Hypertension commonly occurs in conjunction with insulin resistance and other components
of the cardiometabolic syndrome. Insulin resistance plays a significant role in the …

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex, and are dependent …

Background—The anti-ischemic agent trimetazidine improves ejection fraction in heart
failure that is hypothetically linked to inhibitory effects on cardiac free fatty acid (FFA) …

Significance: Over-nutrition and sedentary lifestyle has led to a worldwide increase in
obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of …

Aim To explore the early effects of dapagliflozin on myocardial function and metabolism in
patients with type 2 diabetes without heart failure. Materials and Methods Patients with type …

Heart disease is the leading cause of death in patients with diabetes. 1 Although advances
in medical management and lifestyle interventions have reduced cardiovascular mortality in …

Several clinical studies have shown that insulin resistance is prevalent among patients with
heart failure, but the underlying mechanisms have not been fully elucidated. Here, we report …