Background—Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus
(T2DM). Pioglitazone has been associated with improved cardiac outcome but also with an …

Significance: Mitochondria play a critical role in the physiology of the heart by controlling
cardiac metabolism, function, and remodeling. Accumulation of fragmented and damaged …

Under resting conditions, the failing heart shifts fuel use toward greater glucose and lower
free fatty acid (FFA) oxidation. We hypothesized that chronic metabolic abnormalities in …

Heart failure (HF) is associated with metabolic perturbations, particularly of fatty acids (FAs),
which remain to be better understood in humans. This study aimed at testing the hypothesis …

The incidence and prevalence of heart failure have increased significantly over the past few
decades. Available data suggest that patients with heart failure independent of the aetiology …

Heart failure is a major cause of morbidity and mortality in the world. Cardiac energy
metabolism, specifically fatty acid and glucose metabolism, is altered in heart failure and has …

The hypothesis proposed is that heart failure (HF) is associated with a reactive
hyperadrenergic state that increases circulating plasma free fatty acids (FFAs), which leads …

It has become common sense that the failing heart is an “engine out of fuel”. However,
undisputable evidence that, indeed, the failing heart is limited by insufficient ATP supply is …

Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-
lowering and weight loss medication due to its effects on energy metabolism. In heart failure …

The incretin hormone glucagon-like peptide-1 (GLP-1) and its analogs are currently
emerging as antidiabetic medications. GLP-1 improves left ventricular ejection fraction …