[HTML][HTML] Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes

K Richter, V Grau - Pharmacological Research, 2023 - Elsevier
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the
neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate …

Vasospastic angina: past, present, and future

Z He, X Xu, Q Zhao, H Ding, DW Wang - Pharmacology & Therapeutics, 2023 - Elsevier
Vasospastic angina (VSA) is characterized by episodes of rest angina that are responsive to
short-acting nitrates and are attributable to coronary artery vasospasm. The condition is …

Apolipoprotein (a)/Lipoprotein(a)‐Induced Oxidative‐Inflammatory α7‐nAChR/p38 MAPK/IL‐6/RhoA‐GTP Signaling Axis and M1 Macrophage Polarization Modulate …

YK Lin, CT Yeh, KT Kuo, IH Fong… - Oxidative Medicine …, 2022 - Wiley Online Library
Objective. Apolipoprotein (a)/lipoprotein (a)(Lp (a)), a major carrier of oxidized
phospholipids, and α7‐nicotinic acetylcholine receptor (α7‐nAChR) may play an important …

Coronary artery spasm-related heart failure syndrome: Literature review

MJ Hung, CT Yeh, NG Kounis, I Koniari, P Hu… - International journal of …, 2023 - mdpi.com
Although heart failure (HF) is a clinical syndrome that becomes worse over time, certain
cases can be reversed with appropriate treatments. While coronary artery spasm (CAS) is …

Garcinol attenuates lipoprotein (a)-induced oxidative stress and inflammatory cytokine production in ventricular cardiomyocyte through α7-nicotinic acetylcholine …

NC Chang, CT Yeh, YK Lin, KT Kuo, IH Fong… - Antioxidants, 2021 - mdpi.com
Garcinol, a nicotinic acetylcholine receptor (nAChR) antagonist, has recently been
established as an anti-inflammation agent. However, the molecular mechanism by which …

Acupuncture attenuates cognitive deficits through α7nAChR mediated anti-inflammatory pathway in chronic cerebral hypoperfusion rats

Y Cao, L Wang, LT Lin, XR Wang, SM Ma, NN Yang… - Life Sciences, 2021 - Elsevier
Aims Chronic cerebral hypoperfusion (CCH) elicits inflammatory response, which
contributes to the pathology of cognitive impairment. Several studies demonstrate that the …

Relationship between inflammation and vasospastic angina

MY Hung, MJ Hung - Medicina, 2023 - mdpi.com
Coronary artery spasm (CAS) is a dynamic coronary stenosis causing vasospastic angina
(VSA). However, VSA is a potentially lethal medical condition with multiple presentations …

Smoking as an independent risk factor for hepatocellular carcinoma due to the α7-nachr modulating the JAK2/STAT3 signaling axis

CL Li, YK Lin, HA Chen, CY Huang, MT Huang… - Journal of clinical …, 2019 - mdpi.com
Background: Hepatocellular carcinoma (HCC) is a worldwide health problem. Currently,
there is no effective clinical therapeutic strategy for HCC. Smoking is associated with several …

TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm

X Zhao, J Tian, Y Liu, Z Ye, M Xu, R Huang… - Vascular pharmacology, 2022 - Elsevier
Aim To study the role of toll-like receptors 4-myeloid differentiation factor 88 (TLR4-Myd88)
dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and …

[HTML][HTML] An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework

R Ding, X Ren, Q Sun, Z Sun, J Duan - Journal of Advanced Research, 2023 - Elsevier
Background Nowadays, cigarette smoking remains the leading cause of chronic disease
and premature death, especially cardiovascular disease. As an emerging tobacco product, e …