Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …

We review the cellular and physiological mechanisms responsible for the regulation of blood
flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the …

Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …

A Systems Neuroscience Approach to Migraine: Neuron Skip to Main Content Advertisement
Neuron This journal offers authors two options (open access or subscription) to publish …

The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory
nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

A growing body of evidence supports the modulation of pain by light exposure. As such,
phototherapy is being increasingly utilized for the management of a variety of pain …