Cell and tissue specific metabolism of nucleoside and nucleotide drugs: case studies and implications for precision medicine

EE To - Drug Metabolism and Disposition, 2023 - ASPET
Many clinically used antiviral drugs are nucleoside or nucleotide analog drugs, which have
a unique mechanism of action that requires intracellular phosphorylation. This dependence …

Diagnostic methods and management strategies of herpes simplex and herpes zóster infections

S Mehrmal, R Mojica, AM Guo… - Clinics in Geriatric …, 2024 - geriatric.theclinics.com
Herpesviruses are medium-sized double-stranded DNA viruses. Of more than 80
herpesviruses identified, only 9 human herpesviruses have been found to cause infection in …

Oral Self-Nanoemulsifying System Containing Ionic Liquid of BX795 Is Effective against Genital HSV-2 Infection in Mice

Y Sutar, SK Singh, S Dhoble, J Mali… - ACS Infectious …, 2023 - ACS Publications
BX795 is an emerging drug candidate that has shown a lot of promise as a next-generation
non-nucleoside antiviral agent for the topical treatment of herpes simplex virus type-1 (HSV …

Herpes simplex virus: A practical guide to diagnosis, management, and patient counseling for the primary care clinician

TA Batteiger, CA Rietmeijer - Medical Clinics, 2024 - medical.theclinics.com
Genital herpes is a chronic, lifelong sexually transmitted viral infection, which can cause
recurrent, self-limited genital ulcers. It is caused by herpes simplex virus (HSV) type 1 and …

Performance characteristics of highly automated HSV-1 and HSV-2 IgG testing

KHD Crawford, S Selke, G Pepper… - Journal of Clinical …, 2024 - Am Soc Microbiol
Herpes simplex virus (HSV) infections are one of the most common and stigmatized
infections of humankind, affecting more than 4 billion people around the world and more …

The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study

E Shin, SA Chi, TY Chung, HJ Kim, K Kim… - Alzheimer's Research & …, 2024 - Springer
Background In this study, the risk of dementia in patients with a history of herpes simplex
virus (HSV) or varicella zoster virus (VZV) infection was evaluated. Methods This nationwide …

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review

A Al-Hakim, M Kacar, S Savic - Journal of Clinical Medicine, 2024 - mdpi.com
Common Variable Immunodeficiency (CVID) is a heterogeneous primary immunodeficiency
disorder characterised by impaired antibody production, leading to recurrent infections and …

The more you know? Knowledge about genital herpes and factors affecting adjustment

H DiCaita, PJ Kleinplatz - The Canadian Journal of Human …, 2023 - utpjournals.press
Genital herpes (herpes simplex virus) is a relatively common and recurrent sexually
transmitted infection. Despite its high prevalence, knowledge about the condition can be …

Does genital herpes symptom history predict herpes simplex virus type 2 antibody positivity?

J Perez, KA Lewis, S Vargas… - … journal of STD & …, 2024 - journals.sagepub.com
Background Sexually transmitted infections (STIs) associated with genital ulcer disease due
to herpes simplex virus-2 (HSV-2) are a prominent cause of morbidity and mortality …

Сучасні аспекти епідеміології, діагностики та лікування генітального герпесу на преконцепційному етапі та під час вагітності (Огляд літератури)

ТФ Татарчук, ДГ Коньков, МР Анфілова… - … здоров'я жінки, 2023 - repro-health.com.ua
Анотація Генітальний герпес є одним з найпоширеніших захворювань, що передаються
статевим шляхом. Більшість випадків генітального герпесу діагностують у людей віком …