Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Importance In preclinical studies, thioredoxin-interacting protein overexpression induces
pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death …

OBJECTIVE Previous studies showed that inhibiting lymphocyte costimulation reduces
declining β-cell function in individuals newly diagnosed with type 1 diabetes. We tested …

Insulin resistance is a major contributor to the pathogenesis of several human diseases,
including type 2 diabetes, hypertension, and hyperlipidemia. Notably, insulin resistance and …

The synthesis of mono‐N‐methylated aliphatic primary amines has traditionally been
challenging, requiring noble metal catalysts and high‐pressure H2 for achieving satisfactory …

Type 1 diabetes mellitus (T1DM) is a progressive autoimmune disease that starts long
before a clinical diagnosis is made. The American Diabetes Association recognizes three …

There is a growing understanding that the early phases of type 1 diabetes (T1D) are
characterised by a deleterious dialogue between the pancreatic beta cells and the immune …

Low back pain is usually caused by intervertebral disc degeneration (IVDD), during which
the involvement of oxidation system imbalance and inflammasome activation cannot be …

Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease
resulting from an immune-mediated destruction of pancreatic insulin-secreting β cells. A …