Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Synthetic opioids constitute one of the fastest-growing groups of new psychoactive
substances (NPS) worldwide. With fentanyl analogues being increasingly controlled via …

Several 2-benzylbenzimidazole opioids (also referred to as “nitazenes”) recently emerged
on the illicit market. The most frequently encountered member, isotonitazene, has been …

Novel synthetic opioids continue to emerge on recreational drug markets worldwide. In
response to legislative bans on fentanyl analogues, non-fentanyl structural templates, such …

Background: Synthetic benzimidazole opioids (BOs) are highly potent µ-opioid receptor
agonists with heroin-like effects. Isotonitazene was first available in 2019 in the drug market …

Three new POM-based compounds, with formulae [Na0. 63Ag3 (Htba) 2.37 (tba) 0.63 (H2O)
2 (PMo12O40)]· 4H2O (Ag 3 PMo),[Ag4 (Htba) 4 (H2O) 2 (PMo12O40)](NO3)· H2O (Ag 4 …

Background The emergence of novel synthetic opioids (NSOs) is contributing to the opioid
overdose crisis. While fentanyl analogs have historically dominated the NSO market, a shift …

Recent trends of opioid abuse and related fatalities have highlighted the critical role of Novel
Synthetic Opioids (NSOs). We studied the μ-opioid-like properties of isotonitazene (ITZ) …

Abstract Rationale Novel synthetic opioids (NSOs) are emerging in recreational drug
markets worldwide. In particular, 2-benzylbenzimidazole 'nitazene'compounds are …

Background New synthetic opioids (NSO) constitute one of the fastest-growing group of New
Psychoactive Substances, which emerged on the illicit drug marker in the second half of …