[HTML][HTML] Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Y Yang, S Li, Y Wang, Y Zhao, Q Li - Signal transduction and targeted …, 2022 - nature.com
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
[HTML][HTML] Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors
H Zhou, Q Sun, M Feng, Z Gao, S Jia, L Cao, X Yu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological
functions as post-transcriptional performers, participating in the acquisition or maintenance …
functions as post-transcriptional performers, participating in the acquisition or maintenance …
[HTML][HTML] Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma
H Song, D Liu, L Wang, K Liu, C Chen, L Wang, Y Ren… - Molecular cancer, 2022 - Springer
Background Identification of potential novel targets for reversing resistance to Epidermal
Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise …
Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise …
[HTML][HTML] Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance
J Jia, S Wu, Z Jia, C Wang, C Ju, J Sheng… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Accumulating evidence has revealed that m 6 A modification, the predominant RNA
modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic …
modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic …
[HTML][HTML] IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor …
M Duan, H Liu, S Xu, Z Yang, F Zhang, G Wang… - Genes & diseases, 2024 - Elsevier
Abstract m 6 A methylation is the most frequent modification of mRNA in eukaryotes and
plays a crucial role in cancer progression by regulating biological functions. Insulin-like …
plays a crucial role in cancer progression by regulating biological functions. Insulin-like …
[HTML][HTML] A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal …
S Kendzia, S Franke, T Kröhler, N Golob-Schwarzl… - Molecular Cancer, 2023 - Springer
Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC)
therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC …
therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC …
Inflammatory cytokine-regulated LNCPTCTS suppresses thyroid cancer progression via enhancing Snail nuclear export
C Ma, N Zhang, T Wang, H Guan, Y Huang, L Huang… - Cancer Letters, 2023 - Elsevier
Lymph node metastases are commonly observed in diverse malignancies where they
promote cancer progression and poor outcomes, although the molecular basis is …
promote cancer progression and poor outcomes, although the molecular basis is …
RNA methylation‐related inhibitors: biological basis and therapeutic potential for cancer therapy
H Chen, H Liu, C Zhang, N Xiao, Y Li… - Clinical and …, 2024 - Wiley Online Library
RNA methylation is widespread in nature. Abnormal expression of proteins associated with
RNA methylation is strongly associated with a number of human diseases including cancer …
RNA methylation is strongly associated with a number of human diseases including cancer …
Interleukin-6 promotes the dedifferentiation of papillary thyroid cancer cells
GQ Zhang, C Xi, CT Shen, HJ Song… - Endocrine-Related …, 2023 - erc.bioscientifica.com
Radioiodine treatment is a fundamental therapy for patients with papillary thyroid cancer
(PTC). Sodium/iodide symporter (NIS)-mediated iodine uptake is a prerequisite for the …
(PTC). Sodium/iodide symporter (NIS)-mediated iodine uptake is a prerequisite for the …
[HTML][HTML] Epigenetic Targets and Their Inhibitors in Thyroid Cancer Treatment
K Zhang, J Wang, Z He, X Qiu, R Sa, L Chen - Pharmaceuticals, 2023 - mdpi.com
Although biologically targeted therapies based on key oncogenic mutations have made
significant progress in the treatment of locally advanced or metastatic thyroid cancer, the …
significant progress in the treatment of locally advanced or metastatic thyroid cancer, the …