[PDF][PDF] Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …
The landscape of genomic alterations across childhood cancers
SN Gröbner, BC Worst, J Weischenfeldt, I Buchhalter… - Nature, 2018 - nature.com
Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
The whole-genome landscape of medulloblastoma subtypes
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …
debilitating effects on the developing child, and highlight the need for molecularly targeted …
CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing
Germline copy number variants (CNVs) and somatic copy number alterations (SCNAs) are
of significant importance in syndromic conditions and cancer. Massively parallel sequencing …
of significant importance in syndromic conditions and cancer. Massively parallel sequencing …
Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9 …
editing. However, the events that lead to these karyotypic changes in embryos after Cas9 …
Genome-informed targeted therapy for osteosarcoma
Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially
unchanged for more than 30 years. Osteosarcoma is characterized by widespread and …
unchanged for more than 30 years. Osteosarcoma is characterized by widespread and …
A Big Bang model of human colorectal tumor growth
What happens in early, still undetectable human malignancies is unknown because direct
observations are impractical. Here we present and validate a'Big Bang'model, whereby …
observations are impractical. Here we present and validate a'Big Bang'model, whereby …
[PDF][PDF] Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …
[HTML][HTML] Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges
B Liu, CD Morrison, CS Johnson, DL Trump, M Qin… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Accurate detection of somatic copy number variations (CNVs) is an essential part of cancer
genome analysis, and plays an important role in oncotarget identifications. Next generation …
genome analysis, and plays an important role in oncotarget identifications. Next generation …
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
Background While large-scale cancer genomic projects are comprehensively characterizing
the mutational spectrum of various cancers, so far little attention has been devoted to either …
the mutational spectrum of various cancers, so far little attention has been devoted to either …