Background Human cancers are often sequenced to identify mutations. However, cancers
are spatially heterogeneous populations with public mutations in all cells and private …

Objective Recent studies have integrated copy number variant (CNV) and gene analysis
using target enrichment. Here, we transferred this concept to our routine genetics laboratory …

Simple Summary Tumors contain cancerous cells with different mutations and different types
of non-cancerous cells. It is important to understand the molecular properties of these cells …

Background As the most incident tumor among women worldwide, breast cancer is a
heterogeneous disease. Tremendous efforts have been made to understand how tumor …

Secondary resistance limits the clinical effectiveness of mutation-specific RAS inhibitors in
colorectal cancer. It is unknown whether broad-spectrum RAS inhibitors meet similar …

CalMaTe calibrates preprocessed allele-specific copy number estimates (ASCNs) from DNA
microarrays by controlling for single-nucleotide polymorphism-specific allelic crosstalk. The …

Background In studies of case-parent trios, we define copy number variants (CNVs) in the
offspring that differ from the parental copy numbers as de novo and of interest for their …

Intra-tumor heterogeneity concerns the existence of genetically different subclones within
the same tumor. Single sample quantification of heterogeneity relies on precise …

Prostate cancer is a major health burden, being the second most commonly diagnosed
malignancy in men worldwide. Overtreatment represents a major problem in prostate cancer …

In recent years, cancer immunotherapy has emerged as a highly promising approach to treat
patients with cancer, as the patient's own immune system is harnessed to attack cancer …