[HTML][HTML] Recent developments in essentiality of trivalent chromium and toxicity of hexavalent chromium: implications on human health and remediation strategies
Among the many heavy metals, chromium (Cr) is one of the fascinating ones. In its two most
prevalent oxidation forms, trivalent (Cr 3+) and hexavalent (Cr 6+), Cr has completely …
prevalent oxidation forms, trivalent (Cr 3+) and hexavalent (Cr 6+), Cr has completely …
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
[HTML][HTML] Low-dose metformin targets the lysosomal AMPK pathway through PEN2
T Ma, X Tian, B Zhang, M Li, Y Wang, C Yang, J Wu… - Nature, 2022 - nature.com
Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-
ageing and anticancer effects,,–. For clinical doses of metformin, AMP-activated protein …
ageing and anticancer effects,,–. For clinical doses of metformin, AMP-activated protein …
Acetyl-CoA carboxylases and diseases
Y Wang, W Yu, S Li, D Guo, J He, Y Wang - Frontiers in oncology, 2022 - frontiersin.org
Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …
Targeting mitochondrial biogenesis with polyphenol compounds
Appropriate mitochondrial physiology is an essential for health and survival. Cells have
developed unique mechanisms to adapt to stress circumstances and changes in metabolic …
developed unique mechanisms to adapt to stress circumstances and changes in metabolic …
[HTML][HTML] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
Y Dong, H Chen, J Gao, Y Liu, J Li, J Wang - Journal of molecular and …, 2019 - Elsevier
Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
Fructose-1, 6-bisphosphate and aldolase mediate glucose sensing by AMPK
The major energy source for most cells is glucose, from which ATP is generated via
glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein …
glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein …
The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …
AMPK signalling in health and disease
D Carling - Current opinion in cell biology, 2017 - Elsevier
In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …
Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences
Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …
bipolar disorders and other psychotic disorders. However, they might cause metabolic …