This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Enzymes are highly specific biological catalysts that accelerate the rate of chemical
reactions within the cell. Our knowledge of how enzymes work remains incomplete …

In this chapter we attempt to present a novel prodrug approach which is based on enzyme
models that have been advocated to understand the mechanism by which enzymes catalyze …

As the role of taste receptors in food-intake regulation is being unraveled, agonists and
antagonists of bitter taste receptors will have additional important roles in modulating food …

Abstract prodrugs are bioreversible derivatives of drug molecules that undergo
intermolecular or intramolecular reactions by enzymatic or chemical biotransformation in the …

Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to
release the active parent drug. The prodrug's cleavage can be catalyzed by metabolic …

The conventional old treatment method for cancer therapy is associated with severe side
effects along with several limitations. Therefore, searching and developing new methods for …

The classical approach for delivery of drugs into the central nervous system (CNS) is
associated with adverse effects and it has many limitations. Therefore, extensive efforts have …

The predrug (prodrug) term involves chemically modified inert compound which upon an
administration releases the active parent drug to elicit its pharmacological response within …

Two novel prodrugs of amoxicillin and cephalexin (amoxicillin ProD 1 and cephalexin ProD
1, respectively) were designed and synthesized to improve the stability and bitter sensation …