Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base.
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …

Chordoma is a rare tumor that occurs along the axial spine in pediatrics and adults, with an
incidence of approximately 350 cases per year in the United States. While typically …

Skull base chordomas account for less than 0.2% and chondrosarcomas for less than 0.15%
of all intracranial tumors. Although their clinical and imaging presentations are similar, they …

Introduction Despite encouraging advances in radiation and surgical treatment, chordomas
remain resistant to chemotherapy and local recurrence is common. Although the primary …

Background To assess the role of first-line Molecular Targeted Therapies (MTTs) in
Advanced chordoma (AC) patients. Methods Retrospective study of 80 patients treated …

Paclitaxel has been extensively used in clinics for cancer treatment. However, its limited
solubility in aqueous solution and high occurrence of side effects have also been widely …

Sarcomas are a group of rare mesenchymal malignant tumors that arise from transformed
cells of the mesenchymal connective tissue, which are challenging to treat. The majority of …

In patients with metastatic or unresectable soft tissue and bone sarcoma of extremities and
pelvis, survival is generally poor. The aim of the current systematic review was to analyse …

Background The treatment of clival chordomas remains challenging. Total tumour resection
is often impossible without hampering adjacent anatomical structures and causing functional …

Background Chordoma is a rare malignant tumor of the skull base and axial skeleton, with
an incidence of less than 0.1/100,000 per year. Patients with advanced chordoma have a …