The Blood–Brain Barrier: Composition, Properties, and Roles in Brain Health

B Lacoste, A Prat… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

Neuronal regulation of the blood–brain barrier and neurovascular coupling

L Kaplan, BW Chow, C Gu - Nature Reviews Neuroscience, 2020 - nature.com
To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

Biological effects of indole-3-propionic acid, a gut microbiota-derived metabolite, and its precursor tryptophan in mammals' health and disease

P Konopelski, I Mogilnicka - International journal of molecular sciences, 2022 - mdpi.com
Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

The blood–brain barrier

R Daneman, A Prat - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats

M Ufnal, R Jazwiec, M Dadlez, A Drapala… - Canadian journal of …, 2014 - Elsevier
Background Recent evidence suggests that an elevated plasma trimethylamine N-oxide
(TMAO) level is associated with an increased risk of adverse cardiovascular events in …

Blood brain barrier: A review of its anatomy and physiology in health and disease

Y Sharif, F Jumah, L Coplan, A Krosser… - Clinical …, 2018 - Wiley Online Library
The blood–brain barrier (BBB) is the principal regulator of transport of molecules and cells
into and out of the central nervous system (CNS). It comprises endothelial cells, pericytes …

Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats

T Huć, A Nowinski, A Drapala, P Konopelski… - Pharmacological …, 2018 - Elsevier
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central
(brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the …

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

F Benz, V Wichitnaowarat, M Lehmann, RFV Germano… - Elife, 2019 - elifesciences.org
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular
blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons …

Vasopressin and breathing: review of evidence for respiratory effects of the antidiuretic hormone

M Proczka, J Przybylski… - Frontiers in Plant …, 2021 - frontiersin.org
Vasopressin (AVP) is a key neurohormone involved in the regulation of body functions. Due
to its urine-concentrating effect in the kidneys, it is often referred to as antidiuretic hormone …

The Bradykinin-BDKRB1 Axis Regulates Aquaporin 4 Gene Expression and Consequential Migration and Invasion of Malignant Glioblastoma Cells via a Ca2+ …

DP Sun, YW Lee, JT Chen, YW Lin, RM Chen - Cancers, 2020 - mdpi.com
Glioblastoma multiforme (GBM) is the most common form of brain tumor and is very
aggressive. Rapid migration and invasion of glioblastoma cells are two typical features …