Cardiovascular disease (CVD) remains the leading cause of mortality in women, yet many
people perceive breast cancer to be the number one threat to women's health. CVD and …

Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or
biventricular dilation and impaired contraction that is not explained by abnormal loading …

Truncating mutations in the sarcomere protein titin cause dilated cardiomyopathy due to
sarcomere insufficiency. However, it remains mechanistically unclear how these mutations …

Despite current standard of care, the average 5-year mortality after an initial diagnosis of
heart failure (HF) is about 40%, reflecting an urgent need for new therapeutic approaches …

Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general
population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and …

Background Telomere defects are thought to play a role in cardiomyopathies, but the
specific cell type affected by the disease in human hearts is not yet identified. The aim of this …

Precision medicine promises to dramatically improve patient outcomes and reduce health
care costs through a shift in focus from disease treatment to prevention and individualized …

Dilated cardiomyopathy (DCM) is defined as dilation and/or reduced function of one or both
ventricles and remains a common disease worldwide. An estimated 40% of cases of familial …

Purpose We evaluated genome sequencing (GS) as an alternative to multigene panel
sequencing (PS) for genetic testing in dilated cardiomyopathy (DCM). Methods Forty-two …

Cardiac arrhythmias are frequently seen in patients with dilated cardiomyopathy (DCM) and
can precipitate heart failure and death. In patients with non-ischaemic DCM, evidence for the …