It is verified that failure in cancer therapy by conventional chemotherapeutic agents arise
from cancer heterogeneity. That, a small subpopulation of cancer cells known as “cancer …

Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can
terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self …

Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to
act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of …

Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …

Drug resistance is a major obstacle in the treatment of tumors, which easily lead to relapse
or poor prognosis. Cancer stem cells (CSCs) are regarded as one of the important targets …

Cancer stem cells have been shown to be important in tumorigenesis processes, such as
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …

Background: Glioblastoma multiforme (GBM) is a WHO grade 4 glioma and the most
common malignant primary brain tumour. Recently, there has been outstanding progress in …

Abstract ATP Binding Cassette (ABC) transporters, widely studied in cancer for their role in
drug resistance, have been more recently also considered for their contribution to cancer …

Cancer stem cells (CSCs) are subpopulation of cells which have been demonstrated in a
variety of cancer models and involved in cancer initiation, progression, and development …

BACKGROUND Breast cancer is a common malignant tumor that seriously threatens
women's health. Breast cancer stem cell (CSC)-like cell population may be the main factor …