Background The transcription factor hypoxia inducible factor (HIF)-1 drives tumor growth and
metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate …

Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with
selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into …

Breast cancer (BC) represents aggressive cancer affecting most women's lives globally.
Metastasis and recurrence are the two most common factors in a breast cancer patient's …

The cancer stem cell (CSC) state and epithelial-mesenchymal transition (EMT) activation are
tightly interconnected. Cancer cells that acquire the EMT/CSC phenotype are equipped with …

Quiescence in cancer cells is considered a therapeutic challenge as it confers dormancy in
tumour, hence circumventing inherent anti-neoplastic surveillance system and standard-of …

Cancer is a major threat to human life worldwide. Traditional cancer treatments, such as
chemotherapy and surgery, have major limitations and can cause irreversible damage to …

Breast cancer stem (-like) cells (BCSCs) have been found to be responsible for therapeutic
resistance and disease relapse. BCSCs are difficult to eradicate due to their high resistance …

Objective: Our previous study showed that glioma stem-like cells could be induced to
undergo dedifferentiation under hypoxic conditions, but the mechanism requires further …

The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …

Non‑small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality
rates, which seriously endangers human health. Although treatment methods continue to …