Gonorrhoea

M Unemo, HS Seifert, EW Hook III, S Hawkes… - Nature Reviews …, 2019 - nature.com
The bacterium Neisseria gonorrhoeae causes the sexually transmitted infection (STI)
gonorrhoea, which has an estimated global annual incidence of 86.9 million adults …

Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development

PA Rice, WM Shafer, S Ram… - Annual review of …, 2017 - annualreviews.org
Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains
resistant to many antibiotics are emerging. Appropriate antimicrobial treatment and …

[HTML][HTML] Gonorrhea-an evolving disease of the new millennium

SA Hill, TL Masters, J Wachter - Microbial cell, 2016 - ncbi.nlm.nih.gov
Etiology, transmission and protection: Neisseria gonorrhoeae (the gonococcus) is the
etiological agent for the strictly human sexually transmitted disease gonorrhea. Infections …

Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube

JD Lenz, JP Dillard - Frontiers in immunology, 2018 - frontiersin.org
Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface
infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva …

Progress toward a gonococcal vaccine: the way forward

MW Russell, AE Jerse, SD Gray-Owen - Frontiers in immunology, 2019 - frontiersin.org
The concept of immunizing against gonorrhea has received renewed interest because of the
recent emergence of strains of Neisseria gonorrhoeae that are resistant to most currently …

CEACAM1 structure and function in immunity and its therapeutic implications

WM Kim, YH Huang, A Gandhi, RS Blumberg - Seminars in immunology, 2019 - Elsevier
The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …

Experimental vaccine induces Th1-driven immune responses and resistance to Neisseria gonorrhoeae infection in a murine model

Y Liu, LA Hammer, W Liu, MM Hobbs, RA Zielke… - Mucosal …, 2017 - nature.com
Female mice were immunized intravaginally with gonococcal outer membrane vesicles
(OMVs) plus microencapsulated interleukin-12 (IL-12), and challenged using an established …

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

S Gulati, FJ Beurskens, BJ de Kreuk, M Roza… - PLoS …, 2019 - journals.plos.org
Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody
(mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by> 95 …

Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae

JS Stevens, AK Criss - Current opinion in hematology, 2018 - journals.lww.com
Pathogenesis of Neisseria gonorrhoeae in the female reproduc... : Current Opinion in
Hematology Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract …

The E-cadherin cleavage associated to pathogenic bacteria infections can favor bacterial invasion and transmigration, dysregulation of the immune response and …

CA Devaux, S Mezouar, JL Mege - Frontiers in microbiology, 2019 - frontiersin.org
Once bound to the epithelium, pathogenic bacteria have to cross epithelial barriers to invade
their human host. In order to achieve this goal, they have to destroy the adherens junctions …