Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

N Fujiwara, SL Friedman, N Goossens, Y Hoshida - Journal of hepatology, 2018 - Elsevier
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

[HTML][HTML] YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

L Zhong, D Liao, M Zhang, C Zeng, X Li, R Zhang… - Cancer letters, 2019 - Elsevier
Abstract N 6-methyladenosin (m 6 A) is one of the most pervasive modification of mRNA in
eukaryotes and the m 6 A methyltransferases and demethylases play critical roles in many …

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

K Mahmoud, S Swidan, M El-Nabarawi… - Journal of …, 2022 - Springer
Liver cancer is considered one of the deadliest diseases with one of the highest disease
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …

[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?

R Rauti, M Musto, S Bosi, M Prato, L Ballerini - Carbon, 2019 - Elsevier
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Rethink of EGFR in cancer with its kinase independent function on board

R Thomas, Z Weihua - Frontiers in oncology, 2019 - frontiersin.org
The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …

Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

C Caglayan, FM Kandemir, E Darendelioğlu… - Journal of Trace …, 2019 - Elsevier
Objective Mercury is a global environmental pollutant and is responsible for several organ
pathophysiology including oxidative stress-induced liver disorders. Therefore, the present …

Signaling pathways in hepatocellular carcinoma

T Garcia-Lezana, JL Lopez-Canovas… - Advances in cancer …, 2021 - Elsevier
Despite the recent introduction of new effective systemic agents, the survival of patients with
hepatocellular carcinoma (HCC) at advanced stages remains dismal. This underscores the …

Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment

S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

Progress and prospects of biomarkers in primary liver cancer

YX Gao, TW Yang, JM Yin… - International …, 2020 - spandidos-publications.com
Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation,
recurrence and prognosis prediction of tumors. Primary liver cancer is one of the most …