The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

The normal mechanical functioning of the heart depends on proper electrical functioning,
reflected in the sequential activation of pacemaker cells, and the normal propagation of …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …

Previous studies have documented the expression of four kinetically distinct voltage‐gated
K+ (Kv) currents, Ito, f, Ito, s, IK, slow and Iss, in mouse ventricular myocytes and …

Aging is associated with an increased prevalence of cardiac arrhythmias, which contribute to
higher morbidity and mortality in the elderly. The frequency of cardiac arrhythmias …

Voltage-gated K+ (Kv) channel accessory (β) subunits associate with pore-forming Kv α
subunits and modify the properties and/or cell surface expression of Kv channels in …

After sarcoplasmic reticulum (SR) Ca2+ depletion in intact ventricular myocytes, electrical
activity promotes SR Ca2+ reloading and recovery of twitch amplitude. In ferret, recovery of …

Normal central nervous system development relies on accurate intrinsic cellular programs
as well as on extrinsic informative cues provided by extracellular molecules. Migration of …

Although previous studies have revealed a role for the voltage-gated K+ channel α-subunit
Kv1. 5 (KCNA5) in the generation of the 4-aminopyridine (4-AP)-sensitive component of …

Redox imbalance elicited by oxidative stress contributes to pathogenic remodeling of ion
channels that underlies arrhythmogenesis and contractile dysfunction in the failing heart …