Glaucoma: now and beyond

H Jayaram, M Kolko, DS Friedman, G Gazzard - The Lancet, 2023 - thelancet.com
The glaucomas are a group of conditions leading to irreversible sight loss and characterised
by progressive loss of retinal ganglion cells. Although not always elevated, intraocular …

Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art

L Lambuk, MA Mohd Lazaldin, S Ahmad… - Frontiers in …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are neurons of the visual system that are responsible for
transmitting signals from the retina to the brain via the optic nerve. Glaucoma is an optic …

Ocular drug delivery: advancements and innovations

B Tian, E Bilsbury, S Doherty, S Teebagy, E Wood… - Pharmaceutics, 2022 - mdpi.com
Ocular drug delivery has been significantly advanced for not only pharmaceutical
compounds, such as steroids, nonsteroidal anti-inflammatory drugs, immune modulators …

Risk factors for retinal ganglion cell distress in glaucoma and neuroprotective potential intervention

S Vernazza, F Oddone, S Tirendi, AM Bassi - International Journal of …, 2021 - mdpi.com
Retinal ganglion cells (RGCs) are a population of neurons of the central nervous system
(CNS) extending with their soma to the inner retina and with their axons to the optic nerve …

The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine

S Chen, N Wang, S Xiong, X Xia - EPMA Journal, 2023 - Springer
Background Glaucoma is the leading cause of irreversible blindness worldwide. Emerged
evidence has shown that glaucoma is considered an immune system related disorder. The …

Anti-inflammatory effects of siponimod in a mouse model of excitotoxicity-induced retinal injury

D Basavarajappa, V Gupta, N Chitranshi… - Molecular …, 2023 - Springer
Glaucoma is a leading cause of permanent blindness worldwide and is characterized by
neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage …

S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma

D Basavarajappa, V Gupta, R Vander Wall… - FASEB …, 2023 - researchers.mq.edu.au
Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …

Pharmaceutical approaches to Normal tension Glaucoma

ML Salvetat, F Pellegrini, L Spadea, C Salati… - Pharmaceuticals, 2023 - mdpi.com
Normal tension glaucoma (NTG) is defined as a subtype of primary open-angle glaucoma
(POAG) in which the intraocular pressure (IOP) values are constantly within the statistically …

[HTML][HTML] Cannabinol modulates neuroprotection and intraocular pressure: A potential multi-target therapeutic intervention for glaucoma

RK Somvanshi, S Zou, S Kadhim, S Padania… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Objectives Glaucoma is characterized by progressive damage of the retinal ganglion cells
(RGCs), resulting in irreversible vision loss. Cannabinoids (CBs) ameliorate several factors …

[HTML][HTML] Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

D Basavarajappa, C Galindo-Romero, V Gupta… - Molecular Aspects of …, 2023 - Elsevier
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …