[HTML][HTML] The influence of probiotics on the firmicutes/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease

S Stojanov, A Berlec, B Štrukelj - Microorganisms, 2020 - mdpi.com
The two most important bacterial phyla in the gastrointestinal tract, Firmicutes and
Bacteroidetes, have gained much attention in recent years. The Firmicutes/Bacteroidetes …

[HTML][HTML] The intestinal barrier and current techniques for the assessment of gut permeability

I Schoultz, ÅV Keita - Cells, 2020 - mdpi.com
The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

[HTML][HTML] Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics

KA Jagadeesh, KK Dey, DT Montoro, R Mohan… - Nature …, 2022 - nature.com
Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Identification of environmental factors that promote intestinal inflammation

LM Sanmarco, CC Chao, YC Wang, JE Kenison, Z Li… - Nature, 2022 - nature.com
Genome-wide association studies have identified risk loci linked to inflammatory bowel
disease (IBD)—a complex chronic inflammatory disorder of the gastrointestinal tract. The …

[HTML][HTML] Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial

VC Patel, S Lee, MJW McPhail, K Da Silva, S Guilly… - Journal of …, 2022 - Elsevier
Background & Aims Rifaximin-α is efficacious for the prevention of recurrent hepatic
encephalopathy (HE), but its mechanism of action remains unclear. We postulated that …

Macrophages in intestinal homeostasis and inflammatory bowel disease

LM Hegarty, GR Jones, CC Bain - Nature Reviews Gastroenterology & …, 2023 - nature.com
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

[HTML][HTML] Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines

MI Malkov, CT Lee, CT Taylor - Cells, 2021 - mdpi.com
Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

[HTML][HTML] Clinical insights into the gastrointestinal manifestations of COVID-19

J Kopel, A Perisetti, M Gajendran, U Boregowda… - Digestive diseases and …, 2020 - Springer
The month of December 2019 became a critical part of the time of humanity when the first
case of coronavirus disease 2019 (COVID-19) was reported in the Wuhan, Hubei Province …

Risk of colorectal cancer in inflammatory bowel diseases

MS Nadeem, V Kumar, FA Al-Abbasi, MA Kamal… - Seminars in cancer …, 2020 - Elsevier
Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …

Tumor necrosis factor inhibitors for inflammatory bowel disease

OH Nielsen, MA Ainsworth - New England Journal of Medicine, 2013 - Mass Medical Soc
Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease | NEJM Skip to main content
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