Abstract The NLRP3 (NOD‐, LRR‐, and pyrin domain‐containing protein 3) inflammasome
is a multimeric protein complex that is engaged in the innate immune system and plays a …

Gut microbiome alterations are associated with various cancers including brain tumours
such as glioma and glioblastoma. The gut communicates with the brain via a bidirectional …

Inflammatory caspases sensing lipopolysaccharide (LPS) to drive gasdermin (GSDM)–
mediated pyroptosis is an important immune response mechanism for anti-infection defense …

The blood–brain barrier (BBB) is an interface primarily comprised of brain endothelial cells
(BECs), separating the central nervous system (CNS) from the systemic circulation while …

Toll-like receptors (TLRs) are the most widespread class of membrane-bound innate
immune receptors, responsible of specific pathogen recognition and production of immune …

Brain capillary endothelial cell (s)(BECs) have numerous functions, including their
semipermeable interface-barrier (transfer and diffusion of solutes), trophic (metabolic …

Based on the structural knowledge of TLR5 surface and using blind docking platforms,
peptides derived from a truncated HMGB1 acidic tail from Salmo salar was designed as …

The immune microenvironment plays a critical regulatory role in the pathogenesis of
Helicobacter pylori (H. pylori). Understanding the mechanisms that drive the transition from …

Background Polysulfides are reported to be involved in various important biological
processes. N‐acetyl‐l‐cysteine polysulfide with 2 sulfane sulfur atoms (NAC‐S2) regulates …

Secondary lymphedema is a chronic and incurable disease lacking satisfactory therapeutic
drugs. It primarily results from lymphatic vessel dysfunction resulting from factors such as …