MicroRNAs (miRNAs) are promising tools as biomarkers and therapeutic agents in various
chronic diseases such as osteoporosis, cancers, type I and II diabetes, and cardiovascular …

Background and Objectives: Damage to normal bone tissue following therapeutic irradiation
(IR) represents a significant concern, as IR-induced bone microenvironment disruption can …

A new study shows that decreased cystatin A synthesis in aged epidermis mediates age-
related bone loss, whereas topical treatment that restores cystatin A mitigates this loss. This …

Cellular senescence was first defined as replicative senescence after the works of Hayflick.
Later this concept was extended to many other pathways by which senescence is induced …

Despite advancements in therapeutic techniques, restoring bone tissue after damage
remains a challenging task. Tissue engineering or targeted drug delivery solutions aim to …

Aging is a complex biological process involving multiple interacting mechanisms and is
being increasingly linked to environmental exposures such as wildfire smoke. In this review …

With an increasingly older population, the proportion of patients 85 years or older seeking
interventions to protect their musculoskeletal health is growing. Osteoporosis in the geriatric …

Telomeres are the ends of chromosomes that protect them from DNA damage. There is
evidence to suggest that telomere shortening appears with advanced age. Since aging is a …

The delayed mucosal healing of tooth extraction sockets in diabetes has few known effective
treatment strategies, and its underlying mechanism remains unknown. Senescent cells may …

Physical activity plays a key role in prevention and treatment of several chronic conditions.
Moreover, exercise seems to induce improvements in the bone turnover of osteopenic and …