Improving the hole picture: towards a consensus on the mechanism of nuclear transport

D Cowburn, M Rout - Biochemical Society Transactions, 2023 - portlandpress.com
Nuclear pore complexes (NPCs) mediate the exchange of materials between the
nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and …

Mechanisms of RNA export and nuclear retention

M Khan, S Hou, M Chen, H Lei - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
With the identification of huge amount of noncoding RNAs in recent years, the concept of
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …

NLR we there yet? Nucleocytoplasmic coordination of NLR‐mediated immunity

D Lüdke, Q Yan, PFW Rohmann, M Wiermer - New Phytologist, 2022 - Wiley Online Library
Plant intracellular nucleotide‐binding leucine‐rich repeat immune receptors (NLRs)
perceive the activity of pathogen‐secreted effector molecules that, when undetected …

Structure and mechanics of the human nuclear pore complex basket using correlative AFM-fluorescence superresolution microscopy

A Vial, L Costa, P Dosset, P Rosso, G Boutières… - Nanoscale, 2023 - pubs.rsc.org
Nuclear pore complexes (NPCs) are the only gateways between the nucleus and cytoplasm
in eukaryotic cells. They restrict free diffusion to molecules below 5 nm while facilitating the …

Research progress in nucleus-targeted tumor therapy

S Chen, R Cao, L Xiang, Z Li, H Chen, J Zhang… - Biomaterials …, 2023 - pubs.rsc.org
The nucleus is considered the most important organelle in the cell as it plays a central role in
controlling cell reproduction, metabolism, and cell cycle. The successful delivery of drugs …

Spelling out the roles of individual nucleoporins in nuclear export of mRNA

M Tingey, Y Li, W Yu, A Young, W Yang - Nucleus, 2022 - Taylor & Francis
ABSTRACT The Nuclear Pore Complex (NPC) represents a critical passage through the
nuclear envelope for nuclear import and export that impacts nearly every cellular process at …

Choosing the right exit: How functional plasticity of the nuclear pore drives selective and efficient mRNA export

P Bensidoun, D Zenklusen… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
The nuclear pore complex (NPC) serves as a central gate for mRNAs to transit from the
nucleus to the cytoplasm. The ability for mRNAs to get exported is linked to various upstream …

Unveiling the complexity: Assessing models describing the structure and function of the nuclear pore complex

C Rush, Z Jiang, M Tingey, F Feng… - Frontiers in Cell and …, 2023 - frontiersin.org
The nuclear pore complex (NPC) serves as a pivotal subcellular structure, acting as a
gateway that orchestrates nucleocytoplasmic transport through a selectively permeable …

Interaction of nucleoporins with nuclear transport receptors: a structural perspective

RH Kehlenbach, P Neumann, R Ficner… - Biological …, 2023 - degruyter.com
Soluble nuclear transport receptors and stationary nucleoporins are at the heart of the
nucleocytoplasmic transport machinery. A subset of nucleoporins contains characteristic and …

RNA transport from transcription to localized translation: a single molecule perspective

E Basyuk, F Rage, E Bertrand - RNA biology, 2021 - Taylor & Francis
Transport of mRNAs is an important step of gene expression, which brings the genetic
message from the DNA in the nucleus to a precise cytoplasmic location in a regulated …