Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …

Cell death is a vital process that occurs in billions of cells in the human body every day. This
process helps maintain tissue homeostasis, supports recovery from acute injury, deals with …

Inflammation is a physiological process essential for maintaining homeostatic mechanisms
in human, but however, exaggerated inflammatory responses are closely related to many …

Human plasmacytoid dendritic cells (pDCs) are interleukin-3 (IL-3)-dependent cells
implicated in autoimmunity, but the role of IL-3 in pDC biology is poorly understood. We …

Objective Systemic lupus erythematosus (SLE), the most common form of lupus, is a
multisystemic rheumatic disease with different clinical features that generally affect women …

The gut barrier is a single cell layer that separates gut micro-organisms from the host, and
gut permeability defects result in the translocation of microbial molecules from the gut into …

Renal ischemia is the most common cause of acute kidney injury (AKI) that might be
exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here …

Withanolides, and in particular extracts from Withania somnifera, have been used for over
3,000 years in traditional Ayurvedic and Unani Indian medical systems as well as within …

Objectives Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease
associated with diffuse immune cell dysfunction. CD40–CD40 ligand (CD40L) interaction …

Sphingosine-1-phosphate (S1P), via its G-protein-coupled receptors, is a signaling molecule
with important regulatory properties on numerous, widely varied cell types. Five S1P …