Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Depression is a major mental disease that is ranked as the fourth leading cause of disability.
In order to avoid unwanted adverse reactions, as well as improve efficacy, current …

Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects
around 6.5 million in the United States. Resveratrol is a chemical obtained from natural …

Sesquiterpene lactones (STLs) present a wide range of biological activities, mostly based on
their alkylating capabilities, which underlie their therapeutic potential. These compounds are …

The present study was designed to investigate the putative effect of vitexin, a flavone C–
glucoside present in some drugs, medicinal plants and nutraceuticals, on the central …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Medicinal plants and their extracts are natural remedies with enormous potential for treating
various diseases, including depression and anxiety. In the case of depression, hundreds of …

Depression is a serious widespread psychiatric disorder that affects approximately 17% of
people all over the world. Exploring the neurological mechanisms of the antidepressant …

Abstract Background Sesquiterpene lactones (STLs) make a diverse and huge group of bio-
active constituents that have been isolated from several plant families. However, the greatest …

Background Silymarin is a polyphenolic flavanoid of Silybum marianum, elicited
neuroprotection and antidepressant like activity in stressed model. It was found to increase 5 …