Discovering novel cancer therapies has attracted extreme interest in the last decade. In this
regard, multidrug resistance (MDR) to chemotherapies is a key challenge in cancer …

Despite conventional treatment options including chemoradiation, patients with the most
aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average …

Abstract Background Thymol (2-isopropyl-5-methylphenol) is a colorless crystalline
derivative of cymene, that possesses pleotropic pharmacological properties, including …

Glioblastoma multiforme (GBM) is the most aggressive kind of malignant primary brain tumor
in humans. Given the limitation of Conventional therapeutic strategy, the development of …

The second messenger cyclic guanosine monophosphate (cGMP) is an important regulator
of human (patho-) physiology and has emerged as an attractive drug target. Currently, cGMP …

Solid tumors rely on pathological angiogenesis to meet their metabolic needs and facilitate
their spread. Glioblastoma multiforme (GBM), an aggressive and deadliest brain …

Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the
nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and …

Brain cancers, particularly glioblastoma multiforme (GBM), are challenging health issues
with frequent unmet aspects. Today, discovering safe and effective therapeutic modalities for …

Despite the extensive advancements made in the field of cancer therapy, the outlook of
individuals suffering from glioblastoma multiforme remains highly detrimental. The absence …

Background: Brain cancer is one of the types of cancer that appears with the growth of
cancer cells in the brain. In this experimental study, we investigated and compared the effect …