[HTML][HTML] Neurotoxic soluble amyloid oligomers drive Alzheimer's pathogenesis and represent a clinically validated target for slowing disease progression
M Tolar, J Hey, A Power, S Abushakra - International journal of molecular …, 2021 - mdpi.com
A large body of clinical and nonclinical evidence supports the role of neurotoxic soluble beta
amyloid (amyloid, Aβ) oligomers as upstream pathogenic drivers of Alzheimer's disease …
amyloid (amyloid, Aβ) oligomers as upstream pathogenic drivers of Alzheimer's disease …
[HTML][HTML] Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review
B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …
world. It is an incurable process, most often leading to death. This disease is multifactorial …
[HTML][HTML] Early onset diagnosis in Alzheimer's disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid
Amyloid-β (Aβ) oligomers are implicated in the onset of Alzheimer's disease (AD). Herein,
quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for …
quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for …
[HTML][HTML] Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery
Neurodegenerative diseases are severely debilitating conditions characterized primarily by
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …
[HTML][HTML] Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …
[HTML][HTML] Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …
worldwide. Intracellular transduction pathways that end in the activation of specific …
Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects
J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
Mechanisms of mitochondrial malfunction in Alzheimer's disease: new therapeutic hope
Mitochondria play a critical role in neuron viability or death as it regulates energy
metabolism and cell death pathways. They are essential for cellular energy metabolism …
metabolism and cell death pathways. They are essential for cellular energy metabolism …
Comprehensive review of nutraceuticals against cognitive decline associated with Alzheimer's disease
EE Reza-Zaldívar, DA Jacobo-Velázquez - ACS omega, 2023 - ACS Publications
Nowadays, nutraceuticals are being incorporated into functional foods or used as
supplements with nonpharmacological approaches in the prevention and management of …
supplements with nonpharmacological approaches in the prevention and management of …
[HTML][HTML] The roles of the amyloid beta monomers in physiological and pathological conditions
Amyloid beta peptide is an important biomarker in Alzheimer's disease, with the
amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of …
amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of …