The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …

Mutations that drive uncontrolled cell-cycle progression are requisite events in
tumorigenesis. But evolution has installed in the proliferative programmes of mammalian …

Cellular senescence is a program activated by normal cells in response to various types of
stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity …

Base excision repair (BER) is a frontline repair system that is responsible for maintaining
genome integrity and thus preventing premature aging, cancer and many other human …

Loss of p53 function occurs during the development of most, if not all, tumour types. This
paves the way for genomic instability, tumour-associated changes in metabolism …

The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct
proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour …

Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are
present in most human cancers. Mitogen-dependent, cyclin D-dependent kinases (cdk4 and …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

The HDM2 protein plays an important role in regulating the stability and function of the p53
tumor suppressor protein. In this report, we show that the ribosomal protein L11 can interact …

Although restoration of p53 function is an attractive tumor-specific therapeutic strategy, it
remains unclear whether p53 loss is required only for transition through early bottlenecks in …