Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

The vanilloid receptor TRPV1 is a homotetrameric, non-selective cation channel abundantly
expressed in the nociceptors (c-fibers). TRPV1 is considered as a highly validated pain …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

Endovanilloids are defined as endogenous ligands and activators of transient receptor
potential (TRP) vanilloid type 1 (TRPV1) channels. The first endovanilloid to be identified …

TRP vanilloid 2 (TRPV2) is a nonselective cation channel expressed prominently in medium-
to large-diameter sensory neurons that can be activated by extreme heat (> 52° C). These …

Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is
considered to be an important integrator of various pain stimuli such as endogenous lipids …

We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl) thiophene-2-carboxamide
hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential …

The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1)
channel as pain therapeutics has revealed that these compounds cause hyperthermia in …

The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel
that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons …

Capsaicin (CAP) is a spice-derived substance of the genus Capsicum, which has high
pungency and therapeutic potential. For many years, it has been considered only as an …