Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for
maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy …

The sense of vision begins in the retina, where light is detected and processed through a
complex series of synaptic connections into meaningful information relayed to the brain via …

The Old World macaque monkey and New World common marmoset provide fundamental
models for human visual processing, yet the human ancestral lineage diverged from these …

Glutamate release from rod and cone photoreceptor cells involves presynaptic ribbons
composed largely of the protein RIBEYE. To examine roles of ribbons in rods and cones, we …

Attachment of a detached retina does not always restore vision to pre-injury levels, even if
the attachment is anatomically successful. The problem is due in part to long-term damage …

Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod
photoreceptor ribbon synapses are capable of transmitting signals generated by the …

Vertebrate vision begins with light absorption by rod and cone photoreceptors, which
transmit signals from their synaptic terminals to second-order neurons: bipolar and …

Synaptotagmins are the primary Ca 2+ sensors for synaptic exocytosis. Previous work
suggested synaptotagmin-1 (Syt1) mediates evoked vesicle release from cone …

The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor
(SNARE) superfamily plays a pivotal role in cellular trafficking by facilitating membrane …