Senescence of alveolar epithelial progenitor cells: A critical driver of lung fibrosis
Pulmonary fibrosis comprises a range of chronic interstitial lung diseases (ILDs) that impose
a significant burden on patients and public health. Among these, idiopathic pulmonary …
a significant burden on patients and public health. Among these, idiopathic pulmonary …
[HTML][HTML] Telomeres and telomerase in the control of stem cells
AY Lupatov, KN Yarygin - Biomedicines, 2022 - mdpi.com
Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and
regeneration. This requires significant proliferative potential ensured by sufficient telomere …
regeneration. This requires significant proliferative potential ensured by sufficient telomere …
[HTML][HTML] Cellular senescence: a Troy horse in pulmonary fibrosis
R Wan, L Wang, M Zhu, W Li, Y Duan, G Yu - International journal of …, 2023 - mdpi.com
Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by myofibroblast
abnormal activation and extracellular matrix deposition. However, the pathogenesis of PF …
abnormal activation and extracellular matrix deposition. However, the pathogenesis of PF …
YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner
C Zhang, L Chen, C Xie, F Wang, J Wang… - The EMBO …, 2024 - embopress.org
Accumulation of DNA damage in the lung induces cellular senescence and promotes age-
related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding the …
related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding the …
[HTML][HTML] Senescent AECⅡ and the implication for idiopathic pulmonary fibrosis treatment
T Zhang, J Zhang, C Lv, H Li, X Song - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disease with limited treatment
options. The onset of IPF increases with age, indicating that aging is a major risk factor for …
options. The onset of IPF increases with age, indicating that aging is a major risk factor for …
[HTML][HTML] Genetics in idiopathic pulmonary fibrosis: a clinical perspective
SA Papiris, C Kannengiesser, R Borie, L Kolilekas… - Diagnostics, 2022 - mdpi.com
Background: Unraveling the genetic background in a significant proportion of patients with
both sporadic and familial IPF provided new insights into the pathogenic pathways of …
both sporadic and familial IPF provided new insights into the pathogenic pathways of …
SARS-CoV-2 Spike Protein Induces Oxidative Stress and Senescence in Mouse and Human Lung
JS Greenberger, W Hou, D Shields, R Fisher… - In Vivo, 2024 - iv.iiarjournals.org
Background/Aim: There is concern that people who had COVID-19 will develop pulmonary
fibrosis. Using mouse models, we compared pulmonary inflammation following injection of …
fibrosis. Using mouse models, we compared pulmonary inflammation following injection of …
[HTML][HTML] The role of epithelial cells in fibrosis: mechanisms and treatment
L Luo, W Zhang, S You, X Cui, H Tu, Q Yi, J Wu… - Pharmacological …, 2024 - Elsevier
Fibrosis is a pathological process that affects multiple organs and is considered one of the
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …
[HTML][HTML] Pathological findings associated with SARS-CoV-2 on postmortem core biopsies: correlation with clinical presentation and disease course
JM Ramos-Rincon, C Herrera-García… - Frontiers in …, 2022 - frontiersin.org
Background Autopsies can shed light on the pathogenesis of new and emerging diseases.
Aim To describe needle core necropsy findings of the lung, heart, and liver in decedents with …
Aim To describe needle core necropsy findings of the lung, heart, and liver in decedents with …
[HTML][HTML] Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes
X Zhang, X Hu, Y Zhang, B Liu, H Pan, Z Liu… - Journal of …, 2023 - Springer
Background The rapid increase in production and application of carbon nanotubes (CNTs)
has led to wide public concerns in their potential risks to human health. Single-walled CNTs …
has led to wide public concerns in their potential risks to human health. Single-walled CNTs …