Plant metabolomics: large-scale phytochemistry in the functional genomics era

LW Sumner, P Mendes, RA Dixon - Phytochemistry, 2003 - Elsevier
Metabolomics or the large-scale phytochemical analysis of plants is reviewed in relation to
functional genomics and systems biology. A historical account of the introduction and …

Mass spectrometry in the clinical laboratory

DH Chace - Chemical reviews, 2001 - ACS Publications
The utilization of mass spectrometers in clinical laboratories is undergoing considerable
expansion at the outset of the 21st century. 1, 2 This expansion is largely due to …

Metabolomics by gas chromatography–mass spectrometry: Combined targeted and untargeted profiling

O Fiehn - Current protocols in molecular biology, 2016 - Wiley Online Library
Gas chromatography–mass spectrometry (GC‐MS)–based metabolomics is ideal for
identifying and quantitating small‐molecule metabolites (< 650 Da), including small acids …

FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry

T Kind, G Wohlgemuth, DY Lee, Y Lu… - Analytical …, 2009 - ACS Publications
At least two independent parameters are necessary for compound identification in
metabolomics. We have compiled 2 212 electron impact mass spectra and retention indices …

[HTML][HTML] Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.

MU Ahmed, SR Thorpe, JW Baynes - Journal of Biological Chemistry, 1986 - Elsevier
The chemistry of Maillard or browning reactions of glycated proteins was studied using the
model compound, N alpha-formyl-N epsilon-fructoselysine (fFL), an analog of glycated …

Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicylic acid in sewage water effluent

C Hignite, DL Azarnoff - Life Sciences, 1977 - Elsevier
Chlorophenoxyisobutyrate (CPIB) and salicylic acid, the metabolites of clofibrate and
aspirin, were quantitated by gas chromatography-mass spectrometry in the effluent of a …

High-throughput and multiplexed LC/MS/MRM method for targeted metabolomics

R Wei, G Li, AB Seymour - Analytical chemistry, 2010 - ACS Publications
Target-based metabolomics, focused on a subset of metabolites representative of key
pathways, is a valuable tool for assessing metabolic changes resulting from genetic …

Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry

O Fiehn - TrAC Trends in Analytical Chemistry, 2008 - Elsevier
Gas chromatography coupled to mass spectrometry (GC-MS) is one of the most frequently
used tools for profiling primary metabolites. Instruments are mature enough to run large …

Basics of mass spectrometry based metabolomics

F Courant, JP Antignac, G Dervilly‐Pinel… - …, 2014 - Wiley Online Library
The emerging field of metabolomics, aiming to characterize small molecule metabolites
present in biological systems, promises immense potential for different areas such as …

[HTML][HTML] Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study

A Shrivastava, A Kumar, JD Thomas… - The Lancet Global …, 2017 - thelancet.com
Background Outbreaks of unexplained illness frequently remain under-investigated. In India,
outbreaks of an acute neurological illness with high mortality among children occur annually …