Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

Endothelial cells play the most important role in construction of the blood–brain barrier.
Many studies have opted to use commercially available, easily transfected or immortalized …

Expression and function of histamine H 4 R in central and peripheral nervous system have
been a matter of controversy for more than a decade. The scientific discussion is often …

Histamine is a highly pleiotropic biogenic amine involved in key physiological processes
including neurotransmission, immune response, nutrition, and cell growth and …

The neuromodulator histamine is able to vasorelax in human cerebral, meningeal and
temporal arteries via endothelial histamine 1 receptors (H1Rs) which result in the …

Histamine and its receptors were first described as part of immune and gastrointestinal
systems, but their presence in the central nervous system and importance in behavior are …

Alzheimer's disease (AD) is one of the leading causes for disability and death affecting
millions of people worldwide. Thus, novel therapeutic strategies are needed to reduce brain …

Objective The mechanisms by which histamine increases microvascular permeability remain
poorly understood. We tested the hypothesis that H1 receptor activation disrupts the …

The last volume on histamine in the Handbook of Experimental Pharmacology, entitled
Histamine and Histamine Antagonists, was published as Volume 97 in 1991 and edited by …