Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …

The renin–angiotensin–aldosterone system (RAAS) regulates blood pressure homeostasis
and vascular injury and repair responses. The RAAS was originally thought to be an …

The renin–angiotensin system (RAS) plays a critical role in the pathogenesis of many types
of cardiovascular diseases including cardiomyopathy, valvular heart disease, aneurysms …

The brain renin-angiotensin system (RAS) has available the necessary functional
components to produce the active ligands angiotensins II (AngII), angiotensin III …

Protein and lipid oxidation—mainly by mitochondrial reactive oxygen species (mtROS)—
was proposed as a crucial determinant of health and lifespan. Angiotensin II (Ang II) …

Many studies have implicated both angiotensin II (ANG II) and aldosterone (Aldo) in the
pathogenesis of hypertension, the progression of renal injury, and cardiac remodeling after …

Introduction Angiotensin-converting enzyme (ACE) 2, a homolog of ACE, converts
angiotensin (Ang) II into Ang (1-7), and the vasoprotective effects of Ang (1-7) have been …

The brain renin‐angiotensin system (RAS) has been highlighted as having a pathological
role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia …

We previously demonstrated that mice which overexpress human renin and
angiotensinogen (R+ A+) show enhanced cerebral damage in both in vivo and in vitro …

Dipeptidyl peptidase III (DPP III) cleaves dipeptide residues from the N terminus of
polypeptides ranging from 3 to 10 amino acids in length and is implicated in …