Ulcerative colitis (UC) is a condition at increased risk for colorectal carcinoma (CRC)
development. Nowadays, screening and follow-up programs are routinely performed …

Most sporadic colorectal cancers (CRCs) develop through the adenoma–carcinoma
sequence pathway and are initiated by adenomatous polyposis coli (APC) gene mutations …

Objectives. The APC gene mutation triggers familial adenomatous polyposis (FAP) and
approximately 80% of sporadic colorectal cancers. FAP summarizes the natural history of …

Polyamines and their rate-limiting enzyme, ornithine decarboxylase (ODC), are actively
involved in cell growth and differentiation. The phytoestrogen genistein has been …

AIM: To evaluate if 3 mo oral supplementation with Eviendep® was able to reduce the
number of duodenal polyps in familial adenomatous polyposis (FAP) patients with ileal …

Arginase activity of the intestinal mucosa was tested as a proliferative marker in the
adenoma-carcinoma sequence. The enzyme activity was determined by an end-point …

Objective. The main molecules of cholesterol homeostasis are 3-hydroxy-3-methylglutaryl-
coenzyme A reductase (HMG-CoAR), the key enzyme of the biosynthetic pathway, and the …

The major soy-derived isoflavones such as genistein has been demonstrated to possess
anticarcinogenic activity in animal model systems. The present study was designed to …

Colorectal cancer (CRC) is the fourth most common cancer in the world. If detected at an
early stage, treatment often might lead to cure. Of course prevention is better than cure …

About 10–15% of sporadic colorectal cancers show microsatellite instability (MIN), a mutator
phenotype of mismatch repair genes. It seems that oestrogens may inhibit the pathway to …