Aging is a cellular state characterized by a permanent cessation of cell division and evasion
of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial …

Senescence, a state of irreversible cell-cycle withdrawal, is difficult to distinguish from
quiescence, a state of reversible cell-cycle withdrawal. This difficulty arises because …

Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established
protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle …

Ferroptosis is involved in the pathogenesis of osteoarthritis (OA) while suppression of
chondrocyte ferroptosis has a beneficial effect on OA. However, the molecular mechanism of …

Muscle fiber composition is associated with physical performance, with endurance athletes
having a high proportion of slow-twitch muscle fibers compared to power athletes …

The ratio of fast-and slow-twitch fibers in human skeletal muscle is variable and largely
determined by genetic factors. In this study, we investigated the contribution of microRNA …

Polyploid giant cancer cells (PGCC) are frequently detected in tumors and are increasingly
recognized for their roles in chromosomal instability and associated genome evolution that …

Lamin A is a main constituent of the nuclear lamina and contributes to nuclear shaping,
mechano-signaling transduction and gene regulation, thus affecting major cellular …

Abnormally high expression of lysine-specific demethylase 1 A (LSD1) and DCN1 plays a
vital role in the occurrence, development, and poor prognosis of non-small cell lung cancer …

Introduction Recent studies have shown that epithelial-stromal interactions could play a role
in the development of colorectal cancer. Here, we investigated the role of fibroblasts in the …