Triplex-forming peptide nucleic acids as emerging ligands to modulate structure and function of complex RNAs
Over the last three decades, our view of RNA has changed from a simple intermediate
supporting protein synthesis to a major regulator of biological processes. In the expanding …
supporting protein synthesis to a major regulator of biological processes. In the expanding …
Forced intercalation-induced light-up peptides as fluorogenic indicators for HIV-1 TAR RNA-ligand assay
ETT Lee, Y Sato, AF Ujuagu, S Nishizawa - Analyst, 2024 - pubs.rsc.org
Fluorescence indicators capable of binding to human immunodeficiency virus-1 (HIV-1)
trans-activation responsive (TAR) RNA are powerful tools for the exploratory studies of the …
trans-activation responsive (TAR) RNA are powerful tools for the exploratory studies of the …
[HTML][HTML] Detecting the FLJ22447 lncRNA in Ovarian Cancer with Cyclopentane-Modified FIT-PNAs (cpFIT-PNAs)
ST Mannully, R Mahajna, H Nazzal, S Maree, H Zheng… - Biomolecules, 2024 - mdpi.com
Ovarian cancer (OC) is one of the most lethal gynecologic cancers that is typically
diagnosed at the very late stage of disease progression. Thus, there is an unmet need to …
diagnosed at the very late stage of disease progression. Thus, there is an unmet need to …
[HTML][HTML] Fine-tuning of highly bright benzo [c, d] indole-oxazolopyridine cyanine dye for nucleolar RNA imaging in living cells
N Togashi, M Nagaoka, K Higuchi, Y Yoshino, Y Wu… - Talanta Open, 2024 - Elsevier
Here we report on fine-tuning of highly bright fluorogenic cyanine dye, benzo [c, d] indole-
oxazolo [5, 4-c] pyridine (BIOP: λ em= 570 nm, Φ free= 0.00038, Φ bound= 0.52), recently …
oxazolo [5, 4-c] pyridine (BIOP: λ em= 570 nm, Φ free= 0.00038, Φ bound= 0.52), recently …
モノメチンシアニン蛍光色素による生細胞核小体RNA イメージング
西澤精一， 芳野幸奈， 何夢夢， 樋口啓， 富樫奈央… - 分析化学, 2024 - jstage.jst.go.jp
抄録 一般に既存の核酸結合低分子化合物は DNA 選択性を示すため, RNA イメージングに適用し
うる蛍光性小分子 (色素) の開発は試行錯誤的な状況にある. 実際, 市販されている核小体 RNA …
うる蛍光性小分子 (色素) の開発は試行錯誤的な状況にある. 実際, 市販されている核小体 RNA …