[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
Pain and immunity: implications for host defence
Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Nociceptive pain is a hallmark of many chronic inflammatory conditions including
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …
[HTML][HTML] Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential
The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
A mechanism-based approach to physical therapist management of pain
Pain reduction is a primary goal of physical therapy for patients who present with acute or
persistent pain conditions. The purpose of this review is to describe a mechanism-based …
persistent pain conditions. The purpose of this review is to describe a mechanism-based …
Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research
2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
[HTML][HTML] Cutaneous TRPV1+ neurons trigger protective innate type 17 anticipatory immunity
JA Cohen, TN Edwards, AW Liu, T Hirai, MR Jones… - Cell, 2019 - cell.com
Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines, and
pathogen-associated molecules and are required for innate immunity against some skin …
pathogen-associated molecules and are required for innate immunity against some skin …
Nociception, pain, negative moods, and behavior selection
MN Baliki, AV Apkarian - Neuron, 2015 - cell.com
Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …
The effect of pain on cognitive function: a review of clinical and preclinical research
O Moriarty, BE McGuire, DP Finn - Progress in neurobiology, 2011 - Elsevier
Cognitive impairment is commonly associated with the pain experience. This impairment
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …